Hypersensitivity reaction to Sulfasalazine with Severe Hepatotoxicity
نویسندگان
چکیده
منابع مشابه
Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6.
BACKGROUND A severe adverse reaction to sulfasalazine therapy has been associated with hypersensitivity syndrome, the clinical features of which are similar to infectious mononucleosis. No serologic evidence of viral infections has been reported with this syndrome; however, human herpesvirus 6 infection has not been specifically investigated, which could cause an infectious mononucleosislike sy...
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Paclitaxel, an anti-microtubule chemotherapeutic agent, is known for hypersensitivity reactions. Hypersensitivity reactions associated with paclitaxel may be secondary to its vehicle, Cremophor EL rather than the paclitaxel itself. In contrast, hypersensitivity reactions to parenteral nutrition are uncommon. Both the lipid component and multivitamin have been implicated in hypersensitivity reac...
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BACKGROUND Sulfasalazine is a widely used anti-inflammatory agent in the treatment of inflammatory bowel disease and several rheumatological disorders. Although as many as 20% of treated patients may experience reversible, dose-dependent side effects, less frequent but potentially severe, systemic reactions have also been reported. CASE PRESENTATION A severe systemic reaction to sulfasalazine...
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Background Multiple Drug Hypersensitivity (MDH) was first described by Sullivan et al in 1989 as drug allergies to two or more chemically different drugs proven by in-vivo or in-vitro testing. Pichler et al added to this description by suggesting that there are two subtypes of MDH: one where sensitisation to different drug classes may occur simultaneously; the other, sequentially sometimes even...
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BACKGROUND Sulfonamides are generally classified into 2 groups: antibiotics and non-antibiotics. Recent studies showed that patients allergic to sulfonamide antibiotics do not have a specific risk for an allergy to sulfonamide non-antibiotic. However, the anti-inflammatory drug sulfasalazine represents an important exception. Used in rheumatic diseases, it is classified as a non-antibiotic sulf...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/0016-5085(78)93771-x